Oligonucleotides with internal modifications


All modified DNA oligonucleotides are HPLC purified at no additional charge.
All modifications can also be introduced in RNA.

Adenosine modifications


2-Amino-2'-deoxyadenosine (2-Amino-2'-dA)
3'-Deoxyadenosine, Cordycepin (3'-dA)
7-Deaza-2'-deoxyadenosine (7-Deaza-2'-dA)
8-Bromo-2'-deoxyadenosine (8-Br-2'-dA)
N6-Methyl-2'-deoxyadenosine (N6-Methyl-2'-dA)


top 2-Amino-2'-deoxyadenosine (2-Amino-2'-dA)

  • Increases melting temperature by 3°C per 2-Amino-2'-dA/dT base pair

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product scale amount cat. no. price/coupling
2- Amino-2'-dA 0.05 µmol 5 nmol 5-0230-012 99.00 EUR
0.20 µmol 25 nmol 5-0230-013 135.00 EUR
1.00 µmol 100 nmol 5-0230-014 195.00 EUR

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Structure & Reference


top 3'-Deoxyadenosine, Cordycepin (3'-dA)

  • For blocking the 3'-end of oligonucleotides from extension or ligation

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product scale amount cat. no. price/coupling
3'-dA 0.05 µmol 5 nmol 5-0230-212 99.00 EUR
0.20 µmol 25 nmol 5-0230-213 135.00 EUR
1.00 µmol 100 nmol 5-0230-214 195.00 EUR

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Structure & Reference


top 7-Deaza-2'-deoxyadenosine (7-Deaza-2'-dA)

  • Incorporation of 7-Deaza-2'-dA can reduce secondary structures

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product scale amount cat. no. price/coupling
7-Deaza-2'-dA 0.05 µmol 5 nmol 5-0230-312 99.00 EUR
0.20 µmol 25 nmol 5-0230-313 135.00 EUR
1.00 µmol 100 nmol 5-0230-314 195.00 EUR

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Structure & Reference


top 8-Bromo-2'-deoxyadenosine (8-Br-2'-dA)

  • Halogenated nucleosides are useful for crystallographic studies
  • Useful for probing the structure of Protein-RNA, Protein-DNA and DNA-RNA complexes in crosslinking experiments

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product scale amount cat. no. price/coupling
8-Br-2'-dA 0.05 µmol 5 nmol 5-0230-412 64.00 EUR
0.20 µmol 25 nmol 5-0230-413 95.00 EUR
1.00 µmol 100 nmol 5-0230-414 130.00 EUR

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Structure


top N6-Methyl-2'-deoxyadenosine (N6-Methyl-2'-dA)

  • For studies on methylation effects
  • For blocking of restriction enzymes

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product scale amount cat. no. price/coupling
N6-Me-2'-dA 0.05 µmol 5 nmol 5-0230-512 64.00 EUR
0.20 µmol 25 nmol 5-0230-513 95.00 EUR
1.00 µmol 100 nmol 5-0230-514 115.00 EUR

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Structure



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