Modified RNA oligonucleotides

• 2'-Amino-modified RNA (2'-NH₂-RNA)
  
• 2'-Fluoro-modified RNA (2'-F-RNA)
  
• 2'-O-Methyl-modified RNA (2'-O-Me-RNA)
  
• Inosine-modified RNA (In-RNA)
  

2'-Amino-modified RNA oligonucleotides (2'-NH₂-RNA)

• Stabilization against nucleases
• 2'-Amino-rU and 2'-Amino-rC available
• Number of couplings are limited due to poor coupling efficiency

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product	scale	cat. no.	price/base
2'-Amino-RNA	1.0 µmol	5-0511-014	35.50 EUR

2'-Fluoro-modified RNA oligonucleotides (2'-F-RNA)

• Stabilization against nucleases
• Increase of melting temperature by 2°C per residue
• 2'-F-RNA/RNA duplexes are no substrates for RNase H
• Only 2'-F-rU and 2'-F-rC available

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product	scale	cat. no.	price/base
2'-F-RNA	1.0 µmol	5-0512-014	35.50 EUR
	15.0 µmol	5-0512-015	429.00 EUR

2'-O-Methyl-modified RNA oligonucleotides (2'-O-Me-RNA)

• Provides stabilization against nucleases
• Increases melting temperature by 1.5°C per residue
• 2'-O-Methyl-RNA/RNA hybrids are not recognized by RNase H
• Important for antisense applications

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product	scale	cat. no.	price/base
2'-O-Me-RNA	0.05 µmol	5-0513-012	7.50 EUR
	0.20 µmol	5-0513-013	9.50 EUR
	1.00 µmol	5-0513-014	12.50 EUR
	15.00 µmol	5-0513-015	161.00 EUR

Inosine-modified RNA oligonucleotides (In-RNA)

• Special application in ribozyme technology
• Changes ribozyme cleavage specifity from NUH to NCH

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product	scale	cat. no.	price/base
rI-Coupling	1.0 µmol	5-0514-014	35.50 EUR
	15.0 µmol	5-0514-015	429.00 EUR