Streptamer^® brochures & references

Brochures

	MHC I Streptamer® reversible staining and isolation of cytotoxic CD8+ T-cells (pdf, 596 KB)
	IBA Newsletter, special edition "Streptamer" (PDF, 511 KB)

References

Streptamer technology

Casalegno-Garduño, R.; Schmitt, A.; Yao, J.; Wang, X.; Xun, X.; Freund, M. and Schmitt, M. (2010) Multimer technologies for detection and adoptive transfer of antigen-specific T cells. Cancer Immunology, Immunotherapy 59 (2): 195-202 [Link]

Knabel, M., Franz, T.J., Schiemann, M., Wulf, A., Villmow, B., Schmidt., B., Bernhard, H., Wagner, H. and Busch, D. (2002) Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer. Nature Medicine 8 (6), 631-637. [Link]

Neudorfer, J., Schmidt, B., Huster, K.M., Anderl, F., Schiemann, M., Holzapfel, G., Schmidt, T., Germeroth, L., Wagner, H., Peschel, C., Busch, D. and Bernhard, H. (2007) Reversible HLA multimers (Streptamer) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens. JIM 320, 119-131. [Link]

Yao, J., Bechter, C., Wiesneth, M., Härter, G., Götz, M., Germeroth, L., Guillaume, P., Hasan, F., von Harsdorf, S., Mertens, T., Michel, D., Döhner, H., Bunjes, D., Schmitt., M. and Schmitt, A. (2008) Multimer staining of cytomegalovirus phosphoprotein 65-specific T cells for diagnosis and therapeutic purposes: A comparative study. CID 46, e96-105. [Link]

Cell Therapy

Casalegno-Garduño, R.; Schmitt, A.; Yao, J.; Wang, X.; Xun, X.; Freund, M. and Schmitt, M. (2010) Multimer technologies for detection and adoptive transfer of antigen-specific T cells. Cancer Immunology, Immunotherapy 59 (2): 195-202 [Link]

Knabel, M., Franz, T.J., Schiemann, M., Wulf, A., Villmow, B., Schmidt., B., Bernhard, H., Wagner, H. and Busch, D. (2002) Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer. Nature Medicine 8 (6), 631-637. [Link]

Neudorfer, J., Schmidt, B., Huster, K.M., Anderl, F., Schiemann, M., Holzapfel, G., Schmidt, T., Germeroth, L., Wagner, H., Peschel, C., Busch, D. and Bernhard, H. (2007) Reversible HLA multimers (Streptamer) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens. JIM 320, 119-131. [Link]

Schmitt A., Tonn T., Busch D., Grigoleit G. U., Einsele H., Odendahl M., Germeroth L., Ringhoffer M., Ringhoffer S., Wiesneth M., Greiner J., Michel D., Mertens T., Rojewski M., Marx M., von Harsdorf S., Döhner H., Seifried E., Bunjes D. and Schmitt M. (2010) Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation. TRANSFUSION, Volume 51, pp.591-599. 2 (3): 074-078 [Link]

CD 8+ T-cell development

Stemberger, C.; Huster, K.M.; Koffler, M.; Anderl, F.; Schiemann, M.; Wagner, H.; and Busch, D.H. (2007) A Single naive CD8+ T Cell precursor can develop into diverse effector and memory subsets. Immunity 27 (6): 985-997 [Link] [PDF]

Stemberger, C.; Neuenhahn M.; Buchholz, V. R.and Busch, D.H. (2007) Origin of CD8+ effector and memory T cell subsets. Cellular and Molecular Immunology 4 (6): 399-405 [Link]

Stemberger, C.; Neuenhahn, M.; Gebhardt, F.E.; Schiemann, M.; Buchholz, V.R. and Busch, D.H. (2009) Stem cell-like plasticity of naive and distinct memory CD8+ T cell subsets. Seminars in Immunology 21: 62-68 [Link]

Dendritic Cells

Bauer, C.; Dauer, M.; Schnurr, M.; Jauch, K.; Ruettinger, D.; Conrad,C.; Bruns, C.; Emmerich, B.; Endres, S. and Eigler, A. (2008) Vaccination therapy of pancreatic carcinoma patients with autologous, tumor-lysate pulsed dendritic cells: results of a phase II study. Journal of Clinical Oncology 26 (15S): 2008-3069 [Link]

Dauer, M.; Lam, V.; Arnold, H.; Junkmann, J.; Kiefl, R.; Bauer, C.; Schnurr, M.; Endres, S.; and Eigler, A. (2008) Combined use of toll-like receptor agonists and prostaglandin E2 in the FastDC model: Rapid generation of human monocyte-derived dendritic cells capable of migration and IL-12p70 production. Journal of Immunological Methods 337 (2): 97-105 [Link]

Dauer, M.; Schad, K.; Herten, J.; Junkmann, J.; Bauer, C.; Kiefl, R.; Endres, S. and Eigler, A. (2005) FastDC derived from human monocytes within 48 h effectively prime tumor antigen-specific cytotoxic T cells. Journal of Immunological Methods 302: 145-155 [Link]

Dauer, M.; Schad, K.; Junkmann, J.; Bauer, C.; Herten, J.; Kiefl, R.; Schnurr, M.; Endres, S.; and Eigler, A. (2006) IFN-α promotes definitive maturation of dendritic cells generated by short-term culture of monocytes with GM-CSF and IL-4. Journal of Leukocyte Biology  80: 278-286 [Link] [PDF]

Graft-Versus-Host

Munker, R.; Schmid, C.; Madrigal, J.A. and Kolb, H.J. (2004) An update on graft-versus-host and graft-versus leukemia reactions: a summary of the sixth International Symposium held in Schloss Ellmau, Germany, January 22- 24, 2004. Bone Marrow Transplantation 34: 767-780 [Link] [PDF]

Immuno Therapy

Kapp, M.; Grigoleit, G.U.; Einsele, H. (2008) Immunotherapy post-transplant for infections. The EBMT Handbook Chapter 14 [PDF]

Immune Status

Raeiszadeh, M.; Kopycinski, J.; Paston, S.J.; Diss, T.; Lowdell, M.; Hardy, G.A.D.; Hislop, A.D.; Workman, S.; Dodi, A.; Emery, V. and Webster, A.D. (2006) The T cell response to persistent herpes virus infections in common variable immunodeficiency. Clinical and Experimental Immunology 146 (2): 234–242 [Link] [PDF]

Yao, J., Bechter, C., Wiesneth, M., Härter, G., Götz, M., Germeroth, L., Guillaume, P., Hasan, F., von Harsdorf, S., Mertens, T., Michel, D., Döhner, H., Bunjes, D., Schmitt., M. and Schmitt, A. (2008) Multimer staining of cytomegalovirus phosphoprotein 65-specific T cells for diagnosis and therapeutic purposes: A comparative study. CID 46, e96-105. [Link]

Signalling

Lindquist, J.A. and Schraven, B. (2008) Sparking signals kinases as molecular signal transducers and pharmacological drug targets in inflammation. Ernst Schering Foundation Symposium Proceedings 2007 (3): 43-61

Wang, X.; Simeoni, L.; Lindquist, J.A.; Saez-Rodriguez, J.; Ambach, A.; Gilles, E.D.; Kliche, S.;and Schraven, B.  (2008) Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cells. The Journal of Immunology 180: 6703 -6712 [Link] [PDF]

Vaccines

Bauer, C.; Dauer, M.; Schnurr, M.; Jauch, K.; Ruettinger, D.; Conrad,C.; Bruns, C.; Emmerich, B.; Endres, S. and Eigler, A. (2008) Vaccination therapy of pancreatic carcinoma patients with autologous, tumor-lysate pulsed dendritic cells: results of a phase II study. Journal of Clinical Oncology 26 (15S): 2008-3069 [Link]

Bessa, J.; Schmitz, N.; Hinton, H. J.; Schwarz, K.; Jegerlehner, A. and Bachmann, M. F. (2008) Efficient induction of mucosal and systemic immune responses by virus-like particles administered intranasally: implications for vaccine design. European Journal of Immunology 38 (1): 114-26 [Link] [PDF]

Schmitt, M.; Casalegno-Garduño, R.; Xu, X. and Schmitt, A. (2009) Peptide vaccines for patients with acute myeloid leukemia: future perspective - What's next? Expert Review of Vaccines 8 (10): 1415-1425 [Link]